Interaction of polypyridyl ruthenium (II) complex containing asymmetric ligand with DNA.

نویسندگان

  • Yun-Jun Liu
  • Hui Chao
  • Li-Feng Tan
  • Yi-Xian Yuan
  • Wei Wei
  • Liang-Nian Ji
چکیده

A novel asymmetric bidentate ruthenium (II) complex, [Ru(bpy)(2)(PYNI)](2+) (bpy=2,2'-bipyridine, PYNI=2-(2'-pyridyl)naphthoimidazole), has been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra) and (1)H NMR. The electrochemical behaviors of this complex were studied by cyclic voltammetry. DNA interaction studies suggest that [Ru(bpy)(2)(PYNI)](2+) binds to calf thymus DNA (CT-DNA) in an intercalative mode. Interestingly, this new Ru(II) complex has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation.

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عنوان ژورنال:
  • Journal of inorganic biochemistry

دوره 99 2  شماره 

صفحات  -

تاریخ انتشار 2005